Tadalafil (market name “Cialis” or “Adcirca”) was developed by American pharmaceutical company Lilly.
It is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension.The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum.
Q6: Do you offer custom packaging options? We can tailor packaging to meet your requirements, including bulk orders or smaller quantities for R&D purposes. Under recommended storage conditions (cool, dry place, protected from light and moisture), the shelf life of our Tadalafil API is typically 24 months from the date of manufacture. Q8: Can Tadalafil API be used in compounded medications? Yes, our Tadalafil API is suitable for compounding pharmacies.
However, please consult a pharmacist or the relevant regulatory authority to ensure compliance with local regulations. Generic name:No detailed drug information available Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Studies show that Cialis works very quickly, taking effect in around 15-20 minutes, and has a prolonged effect that can last for up to 36 hours.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 60mg | 180 + 10 Pills | 313.11€ 298.20€ | |
| Cialis Generic | 60mg | 360 + 10 Pills | 570.52€ 543.35€ | |
| Cialis Generic | 20mg | 10 Pills | 31.49€ 29.99€ | |
| Cialis Soft Tabs | 20mg | 270 + 10 Pills | 471.40€ 448.95€ | |
| Cialis Generic | 40mg | 360 + 10 Pills | 477.87€ 455.11€ | |
| Cialis Generic | 60mg | 90 + 6 Pills | 196.67€ 187.30€ | |
| Cialis Black | 80mg | 90 + 6 Pills | 207.88€ 197.98€ | |
| Cialis Generic | 2.5mg | 180 + 10 Pills | 154.86€ 147.49€ | |
| Cialis Generic | 20mg | 20 Pills | 54.72€ 52.11€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Cialis Black | 80mg | 20 Pills | 71.83€ 68.41€ | |
| Cialis Super Active | 20mg | 20 + 4 Pills | 92.35€ 87.95€ |
Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase V inhibitor inhibitor, currently marketed in pill form for cialis online pharmacies treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.
We offer flexible order quantities to suit your needs. Contact us for specific MOQ details based on your requirements. Q3: Can you provide documentation for regulatory compliance? We provide comprehensive documentation, including COA, MSDSs, DMFs, and buy cialis without prescription canada batch release certificates, to support your regulatory submissions. Q4: Is Tadalafil API a controlled substance?
No, Tadalafil API is not classified as a controlled substance. However, the finished pharmaceutical products containing Tadalafil may be subject to regulatory restrictions in some countries. Q5: How long does it take to receive my order? Our standard shipping time is 7~14 days, depending on the destination and shipping method. Expedited shipping options are also available upon request. Tadalafil is synthesized in three steps starting from D-tryptophan methyl ester, by first condensing with piperonal in a Pictet-Spengler cyclization reaction to form the tetrahydro-β-carboline derivative, which is followed by chloroacetylation of the piperidine ring nitrogen and cyclization with methylamine. Tadalafil, 171596-29-5, is a potent PDE5 inhibitor.It received FDA approval for the treatment of erectiledysfunction in December 2003.
| Side Effect | Description | Severity Level | Commonality | Mitigation Tips |
|---|---|---|---|---|
| Headache | Mild to moderate headache | Mild | Common | Stay hydrated, avoid alcohol |
| Dizziness | Feeling lightheaded | Mild | Moderate | Do not operate machinery |
| Flushing | Warmth and redness of face | Mild | Common | Reduce dose or discontinue |
| Priapism | Prolonged erection beyond 4 hours | Severe | Rare | Seek immediate medical attention |
| Nausea | Feeling sick | Mild | Common | Take with food, monitor symptoms |
Because of its half-life of17.5 hours, it is marketed as a 36-hour treatment. Tadalafil ispredominantly metabolized by hepatic enzymes, includingCYP3A4. The concomitant use of CYP3A4 inhibitors suchas ritonavir, indinavir, ketoconazole, as well as moderateCYP3A inhibitors such as erythromycin have been shown toresult in significant increases in tadalafil plasma levels.Much like sildenafil, tadalafil is under clinical investigationfor managing PAH. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum.
Research and Development: Ideal for R&D in pharmaceutical companies exploring new formulations and treatments. It is safe to be shipped by air as common goods. (Contact us for the DGM certificate if it is needed) Manufacturer Documents Available: COA/MSDS/Stability Data Sheet/DGM Certificate Lead Time: 2~3 days for quantities less than 10 KG, 3~4 days for orders less than 50 KG. Trusted Supplier: With years of experience in the pharmaceutical industry, we are a preferred partner for API importers and manufacturers worldwide. Quality Assurance: Our state-of-the-art manufacturing facilities are equipped with advanced technology to ensure consistent quality.
Customer-Centric Approach: We understand your unique needs and provide tailored solutions to meet your production requirements. Sustainability: We are committed to environmentally friendly practices while maintaining product integrity. Global Presence: We serve clients in over 50 countries, ensuring reliable delivery and support. Q1: Is your Tadalafil API compliant with international pharmacopeial standards? Yes, our Tadalafil API meets or exceeds the requirements of USP, EP, BP, and other major pharmacopeias, ensuring its suitability for global pharmaceutical applications. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Tadalafil is different in structure from both sildenafil and vardenafil.
| Standard | Description | Certification Needed | Typical Testing Methods | Importance |
|---|---|---|---|---|
| GMP (Good Manufacturing Practice) | Ensures consistent quality and safety standards | Yes | HPLC, Mass Spectrometry | Ensures product purity and consistency |
| USP Compliance | Follows United States Pharmacopeia standards | Yes | Spectroscopy, Dissolution Testing | Validates quality for medicinal use |
| ISO Certification | International quality management standards | Optional | Various certification audits | Indicates adherence to global quality norms |
It is rapidly absorbed and peaks in concentration (378 μg/L after a 20-mg dose) after 2 hours, displaying a long half-life of 17.5 hours. It also is metabolized by the liver (CYP3A4). Notably, its pharmacokinetics is not clinically influenced by alcohol or food intake or by factors such as diabetes or impaired hepatic or renal function.
Company Name: XI AN CHEN LANG BIO TECH CO., LTD Y37, Xin Dalu Maker Space, 26th Street, 6th Floor, Block C, Trading Plaza, No. 2 South China, City,International Port District, Xi'an, Shaanxi Province. Tadalafil is the principal compound used in the production of pharmaceuticals, particularly for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). As a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), Tadalafil API enhances blood flow to particular areas of the body, offering practical, long-lasting results. Our Tadalafil API is manufactured under strict cGMP (current Good Manufacturing Practices) guidelines, ensuring the highest quality and consistency for your pharmaceutical needs.
WE GUARANTEE SAFE DELIVERY BY ABLE AGENTS OR A 100% REFUND. Our purity is 99% as min with USP standards We have a full refund policy for any quality issues. A tracking number will be provided within 3~4 days after your order. Erectile Dysfunction (ED): Tadalafil API is the active ingredient in medications like Cialis®, helping men achieve and maintain an erection sufficient for satisfactory sexual performance. Pulmonary Arterial Hypertension (PAH): Tadalafil API is used in medications to relax and enlarge pulmonary blood vessels, improving blood flow and reducing symptoms of PAH. Tadalafil is one of the two new PDE5 inhibitors launched for the oral treatment of male erectile dysfunction. Tadalafil is a b-carboline derivative and it is structurally distinct from vardenafil (Levitraw) and sildenafil (Viagraw), both of which are PDE5 inhibitors based on a fused pyrimidine core structure. The most common drug-related adverse events are headache, back pain, dyspepsia, and myalgia. At 10 and 20 mg doses, Tadalafil does not have a significant effect on blood pressure and heart rate and does not result in increased instances of myocardial infarction. Rare reports of prolonged erections greater than 4 h and priapism have been noted with the use of tadalafil.
Priapism, if not treated properly, can result in irreversible damage to the erectile tissue.
Always ask your health care order cialis super force professional for complete information about this product and your specific health needs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. Patients who have an erection lasting greater than 4 h are advised to seek emergency medical attention. D-(-)-Tryptophan methyl ester (175) and 1,3- benzodioxole-5-carboxaldehyde (176) were subjected to a modified Pictet-Spengler reaction to form cis- and transtetrahydro- -carboline tricyclic compounds.
The ciscompound 177 was isolated as a white solid in 42% yield. The basic nitrogen in the piperidine ring of 177 was acylated with chloroacetyl chloride (179) to give compound 180 in 93% yield.
| Medication | Active Ingredient | Onset Time | Duration | Side Effects | Cost (per dose) | Availability |
|---|---|---|---|---|---|---|
| Cialis (Tadalafil) | Tadalafil | 30-60 min | Up to 36 hours | Headache, flushing | $10 - $15 | Widely available |
| Viagra (Sildenafil) | Sildenafil | 30-60 min | 4-6 hours | Visual disturbances | $8 - $12 | Global distribution |
| Levitra (Vardenafil) | Vardenafil | 30-60 min | 4-5 hours | Dizziness, headache | $9 - $14 | Prescription-based |
| Powdered Cialis | Tadalafil in powder form | 30-60 min | Up to 36 hours | Same as oral Cialis | Varies | Online, black market |
Finally, the diketonepiperazine ring was formed by adding 180 to 33% methylamine in ethanol under refluxing conditions and yielded tadalafil (XXII) in 77% as a white solid. Potentially hazardous interactions with other drugs Alpha-blockers: enhanced hypotensive effect - avoid concomitant use.