candesartantadalafil increases effects of candesartan by pharmacodynamic synergism. tadalafil increases effects of once a day cialis candesartan by pharmacodynamic synergism. captopriltadalafil increases effects of captopril by pharmacodynamic synergism. tadalafil increases effects of captopril by pharmacodynamic synergism. carbamazepinecarbamazepine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For patients with ED, monitor response to tadalafil carefully because of potential for decreased effectiveness. carbamazepine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. carvediloltadalafil increases effects of carvedilol by pharmacodynamic synergism. tadalafil increases effects of carvedilol by pharmacodynamic synergism. cenobamatecenobamate will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Increase dose of CYP3A4 substrate, as needed, when coadministered with cenobamate. cenobamate will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. chlorthalidonetadalafil increases effects of chlorthalidone by pharmacodynamic synergism. tadalafil increases effects of chlorthalidone by pharmacodynamic synergism. cimetidinecimetidine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cimetidine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clevidipinetadalafil increases effects of clevidipine by pharmacodynamic synergism.
tadalafil increases effects of clevidipine by pharmacodynamic synergism. clonidinetadalafil increases effects of clonidine by pharmacodynamic synergism. tadalafil increases effects of clonidine by pharmacodynamic synergism.
| Parameter | Value | Description | Note |
|---|---|---|---|
| Absorption time | 30-60 minutes | Time to reach peak plasma levels | Takes about 1 hour for maximum effect |
| Half-life | 17.5 hours | Duration of active drug in body | Allows for once-daily dosing |
| Bioavailability | 80% | Percentage absorbed into circulation | High absorption efficiency |
| Metabolism | Liver (via CYP3A4 enzyme) | Breakdown of drug | Consider interactions with CYP3A4 inhibitors |
clotrimazoleclotrimazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. clotrimazole will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. conivaptanconivaptan will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
bosentanbosentan will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bosentan will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. budesonidebudesonide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. budesonide will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bumetanidetadalafil increases effects of bumetanide by pharmacodynamic synergism.
tadalafil increases effects of bumetanide by pharmacodynamic synergism. bumetanide intranasaltadalafil increases effects of bumetanide intranasal by pharmacodynamic synergism. tadalafil increases effects of bumetanide intranasal by pharmacodynamic synergism. butalbitalbutalbital will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. butalbital will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. conivaptan will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crizotinibcrizotinib increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 60mg | 20 Pills | 65.61€ 62.49€ | |
| Cialis Generic | 10mg | 20 Pills | 48.23€ 45.93€ | |
| Cialis Generic | 60mg | 90 + 6 Pills | 196.67€ 187.30€ | |
| Cialis Super Active | 20mg | 270 + 30 Pills | 661.49€ 629.99€ | |
| Cialis Generic | 60mg | 270 + 10 Pills | 443.96€ 422.82€ | |
| Cialis Generic | 40mg | 270 + 10 Pills | 382.19€ 363.99€ | |
| Cialis Professional | 40mg | 10 Pills | 65.09€ 61.99€ | |
| Cialis Generic | 60mg | 10 Pills | 41.22€ 39.26€ | |
| Cialis Black | 80mg | 90 + 6 Pills | 207.88€ 197.98€ | |
| Cialis Generic | 20mg | 20 Pills | 54.72€ 52.11€ | |
| Cialis Black | 80mg | 10 Pills | 43.27€ 41.21€ | |
| Cialis Professional | 20mg | 60 + 2 Pills | 183.83€ 175.08€ | |
| Cialis Generic | 5mg | 60 + 4 Pills | 86.02€ 81.92€ | |
| Cialis Generic | 2.5mg | 30 + 4 Pills | 51.95€ 49.48€ |
Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. crizotinib increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crofelemercrofelemer increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed.
Monitor blood pressure response to phosphodiesterase type 5 (PDE5) inhibitors in patients receiving concurrent blood pressure lowering therapy. amiloridetadalafil increases effects of amiloride by pharmacodynamic synergism. tadalafil increases effects of amiloride by pharmacodynamic synergism. amiodaroneamiodarone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 inhibitors may reduce tadalafil clearance increasing systemic exposure to tadalafil; increased levels may result in increased associated adverse events.
amiodarone will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. amlodipinetadalafil increases effects of amlodipine by pharmacodynamic synergism. tadalafil increases effects of amlodipine by pharmacodynamic synergism. aprepitantaprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. aprepitant will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
armodafinilarmodafinil will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. armodafinil will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether/lumefantrineartemether/lumefantrine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether/lumefantrine will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. asenapinetadalafil increases effects of asenapine by pharmacodynamic synergism. crofelemer increases levels of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Avoid coadministration of tovorafenib (a weak CYP3A4 inducer) with CYP3A substrates where minimal concentration changes may lead to serious therapeutic failures. If unavoidable, monitor patients for loss of efficacy unless otherwise recommended in the CYP3A4 substrate prescribing information. tovorafenib will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tucatinibtucatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities.
If unavoidable, reduce CYP3A substrate dose according to product labeling. tucatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. acebutololtadalafil increases effects of acebutolol by pharmacodynamic synergism. tadalafil increases effects of acebutolol by pharmacodynamic synergism. acetazolamidetadalafil increases effects of acetazolamide by pharmacodynamic synergism.
tadalafil increases effects of acetazolamide by pharmacodynamic synergism. alfuzosintadalafil increases effects of alfuzosin by pharmacodynamic synergism. tadalafil increases effects of alfuzosin by pharmacodynamic synergism. aliskirentadalafil increases effects of aliskiren by pharmacodynamic synergism. tadalafil increases effects of aliskiren by pharmacodynamic synergism. cyclosporinecyclosporine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclosporine will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dabrafenibdabrafenib will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dabrafenib will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dasatinibdasatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dasatinib will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
tadalafil increases effects of asenapine by pharmacodynamic synergism. atazanaviratazanavir increases levels of tadalafil by decreasing metabolism. atazanavir increases levels of tadalafil by decreasing metabolism. atenololtadalafil increases effects of atenolol by pharmacodynamic synergism. tadalafil increases effects of atenolol by pharmacodynamic synergism.
azilsartantadalafil increases effects of azilsartan by pharmacodynamic synergism. tadalafil increases effects of azilsartan by pharmacodynamic synergism. benazepriltadalafil increases effects of benazepril by pharmacodynamic synergism. tadalafil increases effects of benazepril by pharmacodynamic synergism. betaxololtadalafil increases effects of betaxolol by pharmacodynamic synergism.
tadalafil increases effects of super active cialis betaxolol by pharmacodynamic synergism. bicalutamidebicalutamide will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bicalutamide will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. bisoprololtadalafil increases effects of bisoprolol by pharmacodynamic synergism. tadalafil increases effects of bisoprolol by pharmacodynamic synergism. deferasiroxdeferasirox will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Ingredient | Quantity per Tablet | Function | Notes |
|---|---|---|---|
| Tadalafil | 10 mg | Active pharmaceutical ingredient | Main component for efficacy |
| Lactose | 50 mg | Filler | For tablet bulk |
| Microcrystalline Cellulose | 20 mg | Binder | Helps hold tablet together |
| Magnesium Stearate | 2 mg | Lubricant | Prevents sticking during compression |
| Croscarmellose Sodium | 5 mg | Disintegrant | Ensures tablet dissolves |
deferasirox will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dexamethasonedexamethasone will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dexamethasone will decrease the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diltiazemdiltiazem will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. diltiazem will increase the level or effect of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tadalafil increases effects of doxazosin by pharmacodynamic synergism.