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| Manufacturer | Country of Origin | Certification | Notes |
|---|---|---|---|
| Pfizer | USA | GMP Compliant | Original patent holder |
| Teva Pharmaceuticals | Israel | Approved | Generic manufacturer |
| Aurobindo Pharma | India | GMP Certified | Produces generics |
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| Condition | Explanation | Precaution |
|---|---|---|
| Nitrate Usage | Nitrate medications can cause severe hypotension | Do not combine with nitrate drugs |
| Cardiovascular Disease | May worsen certain heart conditions | Consult cardiologist before use |
| Hypotension | Already low blood pressure | Use with caution |
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| Side Effect | Frequency | Severity | Notes |
|---|---|---|---|
| Headache | Very common | Mild to moderate | Usually transient |
| Flushing | Common | Mild | Due to vasodilation |
| Dyspepsia | Common | Mild | Indigestion |
| Nasal Congestion | Less common | Mild | Sinus tissues affected |
)]TJ 0 Tc 0 Tw T* ( )Tj 0.0005 Tc -0.0005 Tw T* (After patients have taken VIAGRA, it is unknown when nitrates, if necess\ ary, can be safely )Tj 0.0008 Tc -0.0008 Tw T* [(adm)8.6 (i)-1.4 (nistered. Based on the pharm)8.6 (acokinetic profile )]TJ 0.0006 Tc -0.0006 Tw 20.93 0 Td [(of a single 100 m)8.4 (g)0.6 ( oral dose given to healthy )]TJ 0.0009 Tc -0.0009 Tw -20.93 -1.165 Td [(norm)8.7 (al volunteers, the plasm)8.7 (a levels of sildenafil at 24 hours post dose are approxim)8.7 (ately )]TJ 0.0007 Tc -0.0007 Tw 0 -1.18 TD [(2 ng/m)8.5 (L)1.5 ( \(com)8.5 (pared to peak plasm)8.5 (a levels of approxim)8.5 (ately 440 ng/m)8.5 (L)1.5 (\) \(see )]TJ /TT1 1 Tf -0.0014 Tc 0 Tw 30.995 sildenafil online ireland 0 Td (CLINICAL )Tj 0.0004 Tc -0.0004 Tw -30.995 -1.18 Td (PHARMACOLOGY: Pharmacokinetics and Metabolism)Tj /TT0 1 Tf 0.0007 Tc -0.0007 Tw 24.38 0 Td (\). In the following patients: age )Tj 0.001 Tc -0.001 Tw -24.38 -1.165 Td [(>65, hepatic im)8.8 (pairm)8.8 (ent \(e.g., cirrhosis\), severe renal im)8.8 (pairm)8.8 (ent \(e.g., creatinine clearance )]TJ 0.0007 Tc -0.0007 Tw 0 -1.165 TD [(<30 m)8.5 (L)1.5 (/m)8.5 (in\), and concom)8.5 (itant use of potent cytochrom)8.5 (e P450 3A4 inhibitors \(erythrom)8.5 (y)0.7 (cin\), )]TJ T* [(plasm)8.5 (a levels of sildenafil at 24 hours post dose have been found to be 3 to \ 8 tim)8.5 (es higher than )]TJ T* [(those seen in healthy volunteers. Although plasm)8.5 (a levels of sildenafil at 24 hours post dose are )]TJ T* [(m)8.5 (u)0.7 (ch lower than at peak concentration, it is unknown whether nitrates can \ be safely )]TJ 0.001 Tc -0.001 Tw T* [(coadm)8.8 (i)-1.2 (nistered at this tim)8.8 (e point. )]TJ 0 Tc 0 Tw T* ( )Tj 0.0006 Tc -0.0006 Tw T* [(VIAGRA is contraindicated in patients with a known hypersensitivity to a\ ny com)8.4 (ponent of the )]TJ 0.0011 Tc 0 Tw T* (tablet.
)Tj 0 Tc T* ( )Tj T* ( )Tj /TT1 1 Tf -0.0009 Tc 16.4509 Tw 0 -1.18 TD ( WARNINGS )Tj /TT0 1 Tf 0.001 Tc -0.001 Tw 0 -1.155 TD (There is a potential for cardiac risk of sexual activity in patients wit\ h preexisting cardiovascular )Tj 0 -1.165 TD [(disease.
Therefore, treatm)8.8 (ents for erectile)]TJ 0.0002 Tc -0.0002 Tw 16.63 0 Td ( dysfunction, including VIAGRA, should not be )Tj 0.0008 Tc -0.0008 Tw -16.63 -1.165 Td [(generally used in m)8.6 (en for whom)8.6 ( sexual activity is inadvisable because of their underlying )]TJ 0.001 Tc -0.001 Tw T* (cardiovascular status. )Tj 0 Tc 0 Tw T* ( )Tj 0.0008 Tc -0.0008 Tw T* [(VIAGRA has system)8.6 (ic vasodilatory properties that resulted in transient decreases in supin\ e )]TJ 0.0007 Tc -0.0007 Tw T* [(blood pressure in healthy volunteers \(m)8.5 (ean m)8.5 (axim)8.5 (u)0.7 (m)8.5 ( decrease of 8.4/5.5 m)8.5 (m)8.5 (H)2.9 (g\), \(see )]TJ /TT1 1 Tf -0.0001 Tc 0.0001 Tw 0 -1.18 TD (CLINICAL PHARMACOLOGY: Pharmacodynamics)Tj /TT0 1 Tf 0.0008 Tc -0.0008 Tw 23.215 0 Td [(\).