Label: VARDENAFIL HYDROCHLORIDE tablet
It is shows selectivity for PDE5 vs. over 300-fold relative to PDE11 and over 1000-fold relative to PDEs 8, 9, and 10. Vardenafil is frequently used in the treatment erectile dysfunction, and is the active ingredient in Levitra. It has been reported to significantly enhance the SNP-induced, ACh-induced and transmural electrical stimulation-induced relaxation of human trabecular smooth muscle. Vardenafil has been revealed to increase the amount of cGMP in human corpus cavernosum. Store desiccated as supplied at ambient temperature up to 1 year.
Other uses for this medicine
If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. It may not cover all possible information.
How is vardenafil supplied (dosage forms)?
If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more. Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals. Soluble in DMSO at ≥13.3 mg/ml, in ethanol at ≥3.42 mg/ml (with warming and ultrasonic), and in H2O at ≥95 mg/ml Vardenafil has shown a greater selective inhibition towards PDE5 (IC50 = 0.7 nM) vs. PDEs from bovine, with the IC50 values of 180 nM, >10 µM, 2.5 µM, 4 µM and 11 nM for PDE1, PDE2, PDE3, PDE4 and PDE6, respectively. Solutions can be stored at -20°C for up to 3 months. Vardenafil is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 60 + 4 Pills | 71.99€ 68.56€ | |
| Kamagra Effervescent Tablets | 100 mg | 63 + 7 Pills | 171.99€ 163.80€ | |
| Cialis Original | 20mg | 48 + 4 Pills | 224.69€ 213.99€ | |
| Cialis Generic | 5mg | 60 + 4 Pills | 86.02€ 81.92€ | |
| Kamagra Oral Jelly | 100mg | 90 + 8 Sachets | 303.56€ 289.10€ | |
| Kamagra 100 mg | 100 mg | 32 Pills | 121.24€ 115.47€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Apcalis SX Oral Jelly | 20mg | 10 Sachets | 58.75€ 55.95€ | |
| Cialis Black | 80mg | 10 Pills | 43.27€ 41.21€ | |
| Kamagra Polo | 100mg | 272 + 12 Pills | 622.94€ 593.28€ | |
| Cialis Generic | 2.5mg | 20 Pills | 40.73€ 38.79€ | |
| Super Kamagra | 160 mg | 152 + 8 Pills | 729.11€ 694.39€ | |
| Cialis Super Active | 20mg | 120 + 16 Pills | 382.15€ 363.95€ | |
| Tadalista Super Active | 20mg | 120 + 16 Pills | 382.15€ 363.95€ |
Vardenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Vardenafil does not cure erectile dysfunction or increase sexual desire. Vardenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency ceridaviescampaigner co uk virus (HIV). Vardenafil comes as a tablet and a rapidly disintegrating (dissolves in the mouth and is swallowed without water) tablet to take by mouth. It is usually taken as needed, with or without food, 60 minutes before sexual activity. Vardenafil usually should not be taken more often than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take vardenafil less often. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor. If you are taking the rapidly disintegrating tablet, check the blister pack before you take your first dose.
Affordable men's sexual healthcare you can trust.
Some items may interact with your medicine. If you notice any changes in your vision while taking this medication, call your care team as soon as possible. Stop using this medication and call your care team right away if you have a loss of sight in one or both eyes. Contact your care team right away if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of serious problem and must be treated right away to prevent permanent damage.
Biochem/physiol Actions
If you experience symptoms of nausea, dizziness, chest pain or arm pain upon initiation of sexual activity after taking this medication, you should refrain from further activity and call your care team as soon as possible. Drinking alcohol with this medication can increase the risk of side effects. Using this medication does not protect you lovegra tablet or your partner against HIV or other sexually transmitted infections (STIs). Side effects that you should report to your care team as soon as possible: Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat Heart attack—pain or tightness in the chest, shoulders, arms, or jaw, nausea, shortness of breath, cold or clammy skin, feeling faint or lightheaded Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing Low blood pressure—dizziness, feeling faint or lightheaded, blurry vision Stroke—sudden numbness or weakness of the face, arm, or leg, trouble speaking, confusion, trouble walking, loss of balance or coordination, dizziness, severe headache, change in vision Sudden vision loss in one or both eyes Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome): This list may not describe all possible side effects. Keep out of the reach of children and pets.
Visual disturbances
Store between 15 and 30 degrees C (59 and 86 degrees F). Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. Do not use any of the medication from the pack if any of the blisters are torn, broken, or do not contain tablets.
| Point | Explanation | Additional Advice |
|---|---|---|
| Take as prescribed | Usually 10 mg about 30-60 min before activity | Do not exceed recommended dose |
| Food interactions | High-fat meals may delay onset | Take on an empty stomach or low-fat meal |
| Alcohol consumption | May decrease effectiveness or increase side effects | Limit alcohol intake |
| Report side effects or adverse reactions | Such as vision changes, pain, prolonged erections | Seek medical attention immediately |
Follow the package directions to remove the tablet from the blister package. Do not try to push the tablet through the foil. After you remove the tablet from the blister package, immediately place it on your tongue and close your mouth.
- Vardenafil HCl 10mg improves erectile response by increasing blood flow.
- Avoid combining it with other ED medications unless prescribed.
- Potential for interactions with certain heart and blood pressure medicines.
- Use vardenafil with caution under doctor supervision if you have health issues.
- It’s not suitable for women, children, or individuals without ED diagnosis.
- Store in a cool, dry place away from direct sunlight.
- Do not take if you recently used nitric oxide donors.
- Be mindful of timing; take about an hour before intimacy.
- The medication does not produce an erection without sexual stimulation.
- Always adhere to your prescribed dose for best results.
Do not take the rapidly disintegrating tablet with water or other liquids.
5.9 Renal Impairment
Avoid Nitrate Medications: Do not use Vardenafil if you are taking nitrate medications for chest pain, as it can cause a dangerous drop in blood pressure. Limit Alcohol Intake: Reduce or avoid alcohol consumption, as it can increase the risk of side effects and reduce the effectiveness of Vardenafil. Follow Dosage Instructions: Take Vardenafil HCL ODT as prescribed, usually 30 to 60 minutes before sexual activity, and do not exceed the recommended dose. Monitor for Side Effects: Be alert to potential side effects such as sudden vision or hearing loss, prolonged erection, or severe dizziness. Avoid Certain Medications: Do not combine Vardenafil with other erectile dysfunction drugs or medications that can interact negatively, such as certain antibiotics or antifungals.
Before taking vardenafil,
Report Any Changes: Notify your doctor about any new or worsening symptoms while using Vardenafil. Read Patient Information: Review the patient information leaflet provided with the medication to understand proper usage and potential side effects. Inform your doctor if you have cardiovascular issues, such as arrhythmia or high blood pressure, or if you are recovering from surgery. Make sure to provide your doctor with your complete health history. Vardenafil is a medication that treats erectile dysfunction.
Mechanism of Action
ED is the inability to achieve and sustain an erection suitable for sexual intercourse. This medication works by increasing blood flow to your penis, which helps you maintain an erection. Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Your doctor will probably start you on an average dose of vardenafil tablets and increase or decrease your dose depending on your response to the medication. If you are taking the rapidly disintegrating tablets, your doctor will not be able to adjust your dose because the rapidly disintegrating tablets are only available in one strength. If you need a higher or lower dose, your doctor may prescribe the regular tablets instead.
- Vardenafil 10mg is used primarily to improve erectile function in men.
- It’s important to avoid taking multiple doses in a 24-hour period.
- The tablet should be taken with water, not crushed or chewed.
- Potential side effects include headache, flushing, and indigestion.
- Rare but serious reactions include sudden vision or hearing loss.
- Consult your doctor immediately if adverse reactions occur.
- Men with certain health conditions should undergo evaluation before use.
- The drug works by relaxing blood vessels to increase blood flow.
- Avoid excessive alcohol consumption while on vardenafil.
- Store away from light, moisture, and away from children’s reach.
Tell your doctor if vardenafil is not working well or if you are experiencing side effects. Vardenafil rapidly disintegrating tablets cannot be substituted for vardenafil tablets. Be sure that you receive only the type of vardenafil that was prescribed by your doctor.
- Vardenafil HCl 10mg is available in tablet form, usually taken orally.
- It’s important to follow your doctor’s instructions precisely for effectiveness.
- Do not use vardenafil if you have a known allergy to similar drugs.
- Alcohol can increase side effects, such as dizziness and low blood pressure.
- Men with pre-existing eye conditions should proceed with caution.
- Keep a record of any side effects experienced to inform your doctor.
- Use of vardenafil should be part of a broader approach to managing ED.
- Check for drug interactions with your pharmacist before starting therapy.
- Certain health conditions may require dose adjustments or caution.
- The medication is not intended for use as a performance enhancer.
Ask your pharmacist if you have any questions about the type of vardenafil you were given. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. tell your doctor and pharmacist if you are allergic to vardenafil,any other medications.
14.1 Trials in a General Erectile Dysfunction Population
VARDENAFIL (var DEN a fil) treats erectile dysfunction (ED). It works by increasing blood flow to the penis, which helps to maintain an erection. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. They need to know if you have any of these conditions: Eye or vision problems, including a rare inherited eye disease called retinitis pigmentosa Heart disease, angina, a history of heart attack, irregular heart beats, or other heart problems History of blood diseases, such as sickle cell anemia or leukemia An unusual or allergic reaction to vardenafil, other medications, foods, dyes, or preservatives Take this medication by mouth with water. Take it as directed on the prescription label.
Pharmacological Class
The dose is usually taken 1 hour before sexual activity. You should not take this dose more than once per day. You can take it with or without food. If it upsets your stomach, take it with food. Talk to your care team about the use of this medication in children.
General adverse events
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. or any of the ingredients in vardenafil tablets. Ask your pharmacist for a list of the ingredients.
| Country | Approval Status | Regulatory Body | Notes |
|---|---|---|---|
| USA | Approved (FDA) | FDA | Prescription-only medication |
| European Union | Approved (EMA) | EMA | Prescription medication |
| Canada | Approved | Health Canada | Prescription-only |
| Australia | Approved | TGA | Prescription medication |
do not take vardenafil if you are taking or have recently taken riociguat (Adempas) or nitrates such as isosorbide dinitrate (Dilatrate-SR, Isordil, in BiDil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments.
